At Linkpeptide, we provide comprehensive services for the development and production of glycosylated peptides, catering to quantities ranging from milligrams to kilograms. Our expertise in glycosylation enhances the bioavailability, stability, and targeting capabilities of peptides, making them highly valuable for various research and therapeutic applications.
Understanding Glycosylation
Glycosylation is a critical post-translational modification where carbohydrates (glycans) are attached to proteins. This process plays a significant role in numerous cellular functions, including apoptosis, cell growth regulation, infection processes, and immune responses.
Advantages of Glycosylated Peptides
Increased Bioavailability: Enhanced absorption and systemic circulation of peptides.
Improved Metabolic Stability: Resistance to enzymatic degradation, extending peptide half-life.
Targeted Delivery: Directs peptides to specific tissues and organs, improving therapeutic efficacy.
Reduced Clearance: Prolongs peptide presence in the bloodstream.
Enhanced Receptor Binding: Increases interaction with target receptors, boosting biological activity.
Maintained Physical Properties: Prevents issues like precipitation, aggregation, and denaturation.
Types of Glycosylation
N-linked Glycosylation: Attachment of glycans to the nitrogen atom in the side chain of asparagine residues.
O-linked Glycosylation: Attachment of glycans to the oxygen atom in the side chain of serine or threonine residues.
C-Mannosylation: Glycan addition to the carbon atom in tryptophan residues.
GPI Anchor Attachments: Glycosylphosphatidylinositol anchors attaching glycans to the C-terminus of proteins.
Product categories
Custom Glycosylation Services
We offer tailored glycosylation modifications to meet your specific project requirements, including:
Monosaccharides, Disaccharides, and Polysaccharides: Various glycan structures to suit different biological applications.
Advanced Modifications: Incorporation of sialic acid, fucose, and other glycans on the main or side chains of peptides.
Quality Assurance
Our services adhere to stringent quality control measures, ensuring reliable and reproducible results:
Standard Operating Procedures (SOPs): Strict adherence to SOPs for all glycosylation processes.
Validated Methods: Rigorous validation of glycosylation techniques to guarantee accuracy.
Comprehensive Reporting: Detailed analysis and documentation of glycosylation processes and outcomes.
Expert Support
Our team of experts is dedicated to providing continuous support throughout your project. From initial consultation to final delivery, we ensure that your glycosylation needs are met with precision and expertise.