Purotoxin 1

Product Name: Purotoxin 1

CAS No: 1396322-38-5

Purity: 95%

Molar Mass: 3835.5

Chemical Formula: C155H249N51O47S8

Storage: Store at -20℃

Sequence: GYCAEKGIRCDDIHCCTGLKCKCNASGYNCVCRKK-NH2

Target: P2X3 receptor

Application: Purotoxin 1 is a peptide toxin derived from the spider Geolycosa sp. venom, known for its potent blockage of voltage-gated calcium channels (VGCCs), specifically the P/Q-type calcium channels. By binding to these channels, Purotoxin 1 inhibits calcium influx into neurons and other excitable cells, thereby disrupting neurotransmitter release and neuronal excitability. This peptide is extensively utilized in neurophysiological research to study synaptic transmission, neuronal signaling, and the role of calcium channels in neurological disorders such as epilepsy and chronic pain. Its specificity for P/Q-type VGCCs makes Purotoxin 1 a valuable tool in pharmacological studies and potentially in developing therapeutic agents targeting calcium channelopathies.

Reference: Savchenko, G. A., Volkova, T. M., Vasilevskii, A. A., Korol’kova, Y. V., Grishin, E. V., Boichouk, Y. A., & Krishtal, O. A. (2011). Purinergic membrane receptors as targets for the effect of purotoxin 1, a component of venom of spiders from the Geolycosa genus. Neurophysiology, 42, 387-391.