Product Name: Plecanatide
CAS No: 467426-54-6
Purity: 95%
Molar Mass: 1681.89
Chemical Formula: C65H104N18O26S4
Synonyms: Trulance, Guanilib
Storage: Store at -20℃
Sequence: NDECELCVNVACTGCL
Target: guanylate cyclase-C
Application: Plecanatide (CAS: 467426-54-6) is a synthetic analog of uroguanylin, a natural peptide hormone involved in regulating intestinal fluid and electrolyte balance. It functions as a guanylate cyclase-C (GC-C) agonist, specifically targeting GC-C receptors in the gastrointestinal tract. Plecanatide activates GC-C receptors, leading to increased intracellular levels of cyclic guanosine monophosphate (cGMP), which in turn stimulates chloride and bicarbonate secretion into the intestinal lumen, promoting fluid secretion and bowel movement. Plecanatide is used in the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C), providing relief from constipation symptoms and improving bowel habits. In pharmaceutical chemistry, plecanatide’s targeted activation of GC-C receptors represents a novel approach to managing constipation, offering an effective and well-tolerated treatment option for patients with CIC and IBS-C. Its application underscores its importance in gastrointestinal therapeutics and improving quality of life for individuals with chronic constipation. Additionally, ongoing research explores plecanatide’s potential in other gastrointestinal disorders characterized by dysregulated intestinal motility and fluid balance, highlighting its versatility in gastroenterology.
Reference:
Al-Salama, Z. T., & Syed, Y. Y. (2017). Plecanatide: first global approval. Drugs, 77, 593-598.
