H3K4(Me3) (1-20)

Product Name: H3K4(Me3) (1-20)

Purity: 95%

Molar Mass: 2226.6

Chemical Formula: C94H174N35O27

Storage: Store at -20℃

Sequence: ARTKQTARKSTGGKAPRKQL

Application: H3K4(Me3) (1-20) is a synthetic peptide corresponding to the first 20 amino acids of histone H3, trimethylated at the lysine 4 (K4) residue. This specific post-translational modification is a hallmark of actively transcribed gene promoters and is crucial for the regulation of gene expression. Trimethylation of H3K4 facilitates the recruitment of transcriptional activators and chromatin remodelers, thereby promoting an open chromatin state conducive to transcription. The H3K4(Me3) (1-20) peptide is extensively used in epigenetic research to study mechanisms of gene activation, chromatin structure, and the roles of histone modifications in development and disease. Its application is key to understanding transcriptional regulation and developing targeted epigenetic therapies.

Reference: Li, H., Ilin, S., Wang, W., Duncan, E. M., Wysocka, J., Allis, C. D., & Patel, D. J. (2006). Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature, 442(7098), 91-95.