H3K27(Me) (15-34)

Product Name: H3K27(Me) (15-34)

Purity: 95%

Molar Mass: 1994.3

Chemical Formula: C85H152N30O25

Storage: Store at -20℃

Sequence: APRKQLATKAARKSAPATGG

Application: H3K27(Me) (15-34) is a synthetic peptide corresponding to the amino acids 15-34 of histone H3, specifically methylated at the lysine 27 (K27) residue. This post-translational modification plays a pivotal role in the regulation of gene expression by contributing to the formation of repressive chromatin structures. H3K27 methylation is catalyzed by the Polycomb Repressive Complex 2 (PRC2) and is crucial for maintaining stem cell pluripotency and differentiation, as well as for the development and progression of various cancers. The H3K27(Me) (15-34) peptide is a valuable tool in epigenetic research, facilitating studies on chromatin dynamics, gene regulation, and the development of targeted epigenetic therapies.

Reference: Rai, A. N., Vargas, M. L., Wang, L., Andersen, E. F., Miller, E. L., & Simon, J. A. (2013). Elements of the polycomb repressor SU (Z) 12 needed for histone H3-K27 methylation, the interface with E (Z), and in vivo function. Molecular and cellular biology.