Product Name: Difelikefalin
CAS No: 1024828-77-0
Purity: 95%
Molar Mass: 679.85
Chemical Formula: C36H53N7O6
Synonyms: CR-845; FE-202845
Storage: Store at -20℃
Target: kappa opioid receptor
Application: Difelikefalin (CAS: 1024828-77-0) is a synthetic opioid peptide that selectively targets the kappa-opioid receptor (KOR). It acts as an analgesic by binding to KORs in the central nervous system, resulting in the modulation of pain transmission pathways. Difelikefalin has shown efficacy in the management of chronic pruritus (itch) associated with conditions such as chronic kidney disease undergoing hemodialysis and cholestatic liver disease. In pharmaceutical chemistry, difelikefalin’s selective targeting of KOR represents a novel approach to treating pruritus, offering an alternative to traditional antipruritic medications with fewer adverse effects. Its application highlights its importance in addressing the unmet medical need for effective treatments for chronic pruritus, particularly in patients with underlying systemic diseases.
Reference:
Deeks, E. D. (2021). Difelikefalin: first approval. Drugs, 81(16), 1937-1944.
