Product Name: Ziconotide
CAS No: 107452-89-1
Purity: 95%
Molar Mass: 2639.13
Chemical Formula: C102H172N36O32S7
Synonyms: SNX-111
Storage: Store at -20℃
Sequence: CKGKGAKCSRLMYDCCTGSCRSGKC-NH2
Target: N-type calcium channel
Application: Ziconotide (CAS: 107452-89-1) is a synthetic peptide-based analgesic used in the management of severe chronic pain, particularly neuropathic pain. It functions by selectively blocking N-type voltage-gated calcium channels (VGCCs) in the central nervous system, inhibiting the release of neurotransmitters such as glutamate and substance P. This blockade attenuates pain signaling pathways, leading to pain relief. Ziconotide is administered intrathecally, directly into the cerebrospinal fluid, to target pain transmission in the spinal cord. In pharmaceutical chemistry, ziconotide’s targeted inhibition of N-type calcium channels represents a significant advancement in the treatment of refractory chronic pain, offering a specific and effective therapeutic option for patients with neuropathic pain syndromes such as diabetic neuropathy and postherpetic neuralgia. Its application underscores its importance in pain management and improving quality of life for individuals with debilitating pain conditions. Additionally, ongoing research explores ziconotide’s potential in other pain disorders and its role in combination therapies, highlighting its versatility in analgesic therapeutics.
Reference:
