Product Name: Valspodar
CAS No: 121584-18-7
Purity: 95%
Molar Mass: 1214.62
Chemical Formula: C63H111N11O12
Synonyms: Amdray, Psc 833
Storage: Store at -20℃
Target: P-glycoprotein
Application: Valspodar (CAS: 121584-18-7) is a potent inhibitor of P-glycoprotein (P-gp), a membrane transporter protein that plays a crucial role in multidrug resistance (MDR) in cancer cells. By inhibiting P-gp, valspodar can enhance the intracellular accumulation of various chemotherapy drugs, such as doxorubicin and paclitaxel, thereby overcoming MDR and increasing the effectiveness of cancer treatment. Valspodar has been investigated in combination with chemotherapy in clinical trials for various types of cancer, including leukemia, breast cancer, and lung cancer. While initial studies showed promise in overcoming MDR and improving treatment outcomes, further research is needed to optimize dosing regimens and minimize potential side effects associated with valspodar, such as drug interactions and toxicity. Despite challenges, valspodar represents a valuable approach to addressing MDR in cancer therapy and continues to be of interest in oncology research.
