TLQP 21

Product Name: TLQP 21

CAS No: 869988-94-3

Purity: 95%

Molar Mass: 2432.8

Chemical Formula: C107H170N40O26

Storage: Store at -20℃

Sequence: TLQPPASSRRRHFHHALPPAR

Application: TLQP-21 is a bioactive peptide derived from the larger VGF precursor protein, involved in modulating energy metabolism, stress response, and pain. It exerts its effects through binding to the complement C3a receptor 1 (C3aR1) and possibly other receptors, influencing processes such as lipolysis, inflammation, and glucose homeostasis. TLQP-21 has been shown to enhance fat mobilization, reduce food intake, and improve glucose tolerance, making it a promising candidate for research in obesity, diabetes, and metabolic disorders. Its regulatory role in energy balance and inflammation also suggests potential therapeutic applications in treating metabolic syndrome and related conditions.

Reference: El Gaamouch, F., Audrain, M., Lin, W. J., Beckmann, N., Jiang, C., Hariharan, S., … & Salton, S. R. (2020). VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice. Molecular neurodegeneration, 15, 1-19.