Tertiapin LQ

Purity: 95%

Molar Mass: 2428.0

Chemical Formula: C106H179N33O24S4

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Product Name: Tertiapin LQ

Purity: 95%

Molar Mass: 2428.0

Chemical Formula: C106H179N33O24S4

Storage: Store at -20℃

Sequence: ALCNCNRIIIPLQCWKKCGKK

Application: Tertiapin LQ is a peptide toxin derived from honey bee venom, specifically designed to block inward rectifier potassium (Kir) channels, particularly Kir1.1 and Kir3.1/3.4. By inhibiting these channels, Tertiapin LQ modulates cellular excitability and ion transport. It is extensively used in cardiovascular and renal research to study the roles of Kir channels in heart rhythm regulation, renal function, and insulin secretion. Additionally, Tertiapin LQ has potential applications in developing therapeutic agents for cardiac arrhythmias, hypertension, and other conditions involving dysfunctional potassium channel activity.

Reference: Okada, M., Kozaki, I., & Honda, H. (2020). Antidepressive effect of an inward rectifier K+ channel blocker peptide, tertiapin-RQ. Plos one, 15(11), e0233815.