Product Name: Terlipressin
CAS No: 14636-12-5
Purity: 95%
Molar Mass: 1227.37
Chemical Formula: C52H74N16O15S
Synonyms: 1-Triglycyl-8-lysine Vasopressin, Terlipressinum
Storage: Store at -20℃
Sequence: GGGCYFQNCPKG
Target: Vasopressin V1 receptor
Application: Terlipressin (CAS: 14636-12-5) is a synthetic analog of vasopressin, also known as antidiuretic hormone (ADH), used primarily in the management of hepatorenal syndrome (HRS) and variceal bleeding. It acts as a prodrug that is metabolized in vivo to form lysine vasopressin, which binds to vasopressin receptors, particularly V1 receptors in vascular smooth muscle cells. Terlipressin induces vasoconstriction of splanchnic vessels, reducing portal hypertension and improving systemic vascular resistance. This mechanism helps to alleviate complications such as renal hypoperfusion in HRS and control bleeding from esophageal varices. In pharmaceutical chemistry, terlipressin’s targeted action on vasopressin receptors represents a significant advancement in the management of complications associated with liver cirrhosis, offering a specific and effective therapeutic approach to improve outcomes in patients with HRS and variceal bleeding. Its application underscores its importance in hepatology and critical care medicine, providing life-saving interventions for patients with advanced liver disease. Additionally, ongoing research explores terlipressin’s potential in other conditions characterized by vasodilatory shock and renal impairment, highlighting its versatility in cardiovascular and renal therapeutics.
