Product Name: Spadin
CAS No: 1270083-24-3
Purity: 95%
Molar Mass: 2012.3
Chemical Formula: C96H142N26O22
Storage: Store at -20℃
Sequence: YAPLPRWSGPIGVSWGLR
Target: TREK-1 channel blocker
Application: Spadin is a peptide derived from the propeptide sortilin that acts as a potent antidepressant by targeting the TREK-1 (TWIK-related K+ channel 1) potassium channel. By inhibiting TREK-1, Spadin enhances neuronal excitability and increases the levels of neurotrophic factors, which are crucial for neurogenesis and synaptic plasticity. This peptide shows significant potential in the treatment of major depressive disorder, offering a rapid onset of antidepressant effects with fewer side effects compared to traditional therapies. Spadin’s unique mechanism of action positions it as a promising candidate for novel antidepressant development and advancing mental health research.
