Serelaxin

Product Name: Serelaxin

CAS No: 99489-94-8

Purity: 95%

Molar Mass: 5963.04

Chemical Formula: C256H408N74O74S8

Synonyms: RLX030

Storage: Store at -20℃

Application: Serelaxin (CAS: 99489-94-8) is a recombinant form of human relaxin-2, a hormone naturally produced during pregnancy. It functions as a vasodilator and has been investigated for its potential therapeutic applications in various cardiovascular conditions, particularly heart failure. Serelaxin acts by promoting vasodilation, reducing inflammation, and exerting anti-fibrotic effects, ultimately improving cardiac function and reducing symptoms associated with heart failure. Clinical trials have shown promising results, demonstrating serelaxin’s ability to improve hemodynamic parameters, reduce hospitalizations, and improve mortality rates in patients with acute heart failure. Despite initial enthusiasm, further research is needed to fully elucidate serelaxin’s mechanisms of action and optimize its clinical use in heart failure management.

Reference:

Bani, D. (2020). Recombinant human H2 relaxin (serelaxin) as a cardiovascular drug: aiming at the right target. Drug Discovery Today, 25(7), 1239-1244.

Metra, M., Teerlink, J. R., Cotter, G., Davison, B. A., Felker, G. M., Filippatos, G., … & Gimpelewicz, C. (2019). Effects of serelaxin in patients with acute heart failure. New England Journal of Medicine, 381(8), 716-726.