Product Name: Pexiganan
CAS No: 147664-63-9
Purity: 95%
Molar Mass: 2477.17
Chemical Formula: C122H210N32O22
Synonyms: TVF29Q70Q1
Storage: Store at -20℃
Sequence: GIGKFLKKAKKFGKAFVKILKK
Target: antibacterial
Application: Pexiganan (CAS: 147664-63-9) is a synthetic antimicrobial peptide derived from magainin, a peptide found in the skin of the African clawed frog. Pexiganan exhibits broad-spectrum antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). Its mechanism of action involves disrupting bacterial cell membranes, leading to cell lysis and death. Pexiganan has shown promise in the treatment of various bacterial infections, including diabetic foot ulcers, burns, and skin infections. It is typically administered topically as a cream or gel formulation. Clinical trials have demonstrated the efficacy and safety of pexiganan in treating infected wounds, with favorable outcomes in terms of bacterial eradication and wound healing. Despite its potential, further research is needed to optimize dosing regimens and investigate its potential for systemic use. Pexiganan represents a promising option for the management of bacterial infections, particularly in cases where conventional antibiotics may be ineffective due to resistance or limited penetration into infected tissues.
