Pam2CSK4 Biotin

Product Name: Pam2CSK4 Biotin

Purity: 95%

Molar Mass: 1724.4

Chemical Formula: C87H162N14O16S2

Synonyms: AKOS024458269

Storage: Store at -20℃

Sequence: XSKKKX

Target: Toll-like receptor 2/6

Application: Pam2CSK4 Biotin is a modified form of the synthetic lipopeptide Pam2CSK4, where biotin is conjugated to facilitate detection and affinity-based assays. This peptide retains the biological activity of Pam2CSK4 as a potent agonist for Toll-like receptor 2 (TLR2). Upon binding to TLR2, Pam2CSK4 Biotin activates innate immune responses, including the production of pro-inflammatory cytokines and chemokines. Its biotin tag allows for easy detection and purification using streptavidin-based methods, making it invaluable in immunological research for studying TLR2-mediated signaling pathways, host-pathogen interactions, and the development of immune responses.

Reference: Arai, Y., Inuki, S., & Fujimoto, Y. (2018). Site-specific effect of polar functional group-modification in lipids of TLR2 ligands for modulating the ligand immunostimulatory activity. Bioorganic & Medicinal Chemistry Letters, 28(9), 1638-1641.