Pam2CSK4

CAS No: 868247-72-7

Purity: 95%

Molar Mass: 1271.8

Chemical Formula: C65H126N10O12S

 

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Product Name: Pam2CSK4

CAS No: 868247-72-7

Purity: 95%

Molar Mass: 1271.8

Chemical Formula: C65H126N10O12S

Storage: Store at -20℃

Sequence: {(2R)-2,3-Bis(1-oxohexadecyl)oxy]propyl}-CSKKKK

Target: TLR2

Application: Pam2CSK4 is a synthetic lipopeptide that serves as a potent agonist for Toll-like receptor 2 (TLR2). It consists of a diacylated cysteine-serine-lysine sequence linked to a lipid tail. Upon binding to TLR2, Pam2CSK4 activates signaling pathways that trigger the innate immune response, leading to the production of pro-inflammatory cytokines and chemokines. This peptide is extensively used in immunological research to study host-pathogen interactions, immune system activation, and the development of immune responses. Pam2CSK4 is also employed in vaccine adjuvant research to enhance the efficacy of vaccines by stimulating robust immune reactions against pathogens.

Reference: Souza, J. A. C. D., Magalhães, F. A. C., Oliveira, G. J. P. L. D., De Molon, R. S., Zuanon, J. A., & Souza, P. P. C. D. (2020). Pam2CSK4 (TLR2 agonist) induces periodontal destruction in mice. Brazilian Oral Research, 34, e012.