Omiganan

CAS No: 204248-78-2

Purity: 95%

Molar Mass: 1779.15

Chemical Formula: C90H127N27O12

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Product Name: Omiganan

CAS No: 204248-78-2

Purity: 95%

Molar Mass: 1779.15

Chemical Formula: C90H127N27O12

Storage: Store at -20℃

Sequence: ILRWPWWPWRRK

Target: antibacterial

Application: Omiganan (CAS: 204248-78-2) is a synthetic antimicrobial peptide with broad-spectrum activity against bacteria, fungi, and some viruses. It is derived from indolicidin, a natural antimicrobial peptide found in bovine neutrophils. Omiganan works by disrupting microbial cell membranes, leading to cell lysis and death. It has demonstrated efficacy against a wide range of pathogens, including antibiotic-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). Omiganan has been investigated for various clinical applications, including the treatment of skin and wound infections, oral mucositis, and urinary tract infections. It is available in topical formulations such as creams, gels, and mouth rinses. Clinical trials have shown promising results, with omiganan demonstrating efficacy in reducing bacterial burden and promoting wound healing. Additionally, its broad-spectrum activity and low propensity for resistance make it a valuable option for the management of multidrug-resistant infections. Despite its potential, further research is needed to optimize dosing regimens, evaluate long-term safety, and explore additional therapeutic indications for omiganan. Overall, omiganan represents a promising antimicrobial agent with the potential to address the growing challenge of antimicrobial resistance and improve outcomes for patients with infectious diseases.

Reference: Niemeyer‐van der Kolk, T., van der Wall, H., Hogendoorn, G. K., Rijneveld, R., Luijten, S., van Alewijk, D. C., … & van Doorn, M. B. (2020). Pharmacodynamic effects of topical omiganan in patients with mild to moderate atopic dermatitis in a randomized, placebo‐controlled, phase II trial. Clinical and Translational Science, 13(5), 994-1003.