Product Name: Murepavadin
CAS No: 944252-63-5
Purity: 95%
Molar Mass: 1553.81
Chemical Formula: C73H112N22O16
Synonyms: POL7080, RO7033877
Storage: Store at -20℃
Sequence: Cyclo(AS-{d-Pro}-PTWI-{Dab}-{Orn}-{d-Dab}-{Dab}-W-{Dab}-{Dab})
Target: antibiotic
Application: Murepavadin (CAS: 944252-63-5) is a novel synthetic antibiotic that belongs to the class of outer membrane protein-targeting antibiotics known as polymyxins. It specifically targets and disrupts the outer membrane of Gram-negative bacteria, leading to cell death. Murepavadin exhibits potent activity against multidrug-resistant strains of Pseudomonas aeruginosa, including those that are resistant to commonly used antibiotics such as carbapenems. Due to its mechanism of action and specificity, murepavadin has the potential to address the growing threat of antibiotic resistance, particularly in hospital-acquired infections caused by Pseudomonas aeruginosa. Clinical trials have demonstrated the efficacy and safety of murepavadin in the treatment of ventilator-associated pneumonia and other infections caused by Pseudomonas aeruginosa. However, further research is needed to optimize dosing regimens, evaluate its efficacy in different patient populations, and assess the risk of resistance development. Murepavadin represents a promising addition to the antibiotic armamentarium, offering a new treatment option for serious infections caused by multidrug-resistant Gram-negative bacteria.
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