Product Name: Motixafortide Acetate
CAS No: 664334-36-5
Molar Mass: 2159.52
Chemical Formula: C97H144FN33O19S
Synonyms: BKT140 4-fluorobenzoyl
Storage: Store at -20℃
Sequence: RRXCYXKKPYRXCR
Target: CXCR4
Application: Motixafortide acetate (CAS: 664334-36-5) is a synthetic peptide drug that acts as a CXCR4 antagonist. CXCR4 is a chemokine receptor involved in cell migration and homing, particularly in hematopoietic stem cells and immune cells. Motixafortide acetate functions by competitively binding to CXCR4 receptors, inhibiting the interaction between CXCR4 and its ligand, CXCL12 (also known as stromal cell-derived factor 1, SDF-1). This blockade disrupts signaling pathways critical for tumor cell migration, invasion, and metastasis, as well as for stem cell mobilization. Motixafortide acetate is being investigated for its potential in the treatment of various cancers, including acute myeloid leukemia (AML), multiple myeloma, and certain solid tumors. In pharmaceutical chemistry, motixafortide acetate’s targeted antagonism of CXCR4 represents a promising approach to cancer therapy, offering a specific and effective means of inhibiting tumor progression and metastasis. Ongoing clinical trials aim to further evaluate its safety and efficacy in different cancer types, with the goal of providing a valuable addition to anticancer treatment regimens.
Reference:
