MAUROCALCIN

Product Name: MAUROCALCIN

Purity: 95%

Molar Mass: 3859.0

Chemical Formula: C156H260N56O46S6

Synonyms: MCa, Maurocalcin

Storage: Store at -20℃

Sequence: GDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR

Application: Maurocalcin is a peptide toxin derived from the venom of the scorpion Scorpio maurus palmatus. It specifically targets and modulates ryanodine receptors (RyR), which are critical for calcium ion release in muscle cells. By binding to these receptors, Maurocalcin enhances calcium ion influx, leading to potent activation of intracellular calcium signaling pathways. This unique mechanism positions Maurocalcin as a valuable tool in studying calcium dynamics and muscle physiology. Additionally, its potential therapeutic applications include the treatment of conditions involving dysfunctional calcium homeostasis, such as certain muscle disorders and cardiac arrhythmias.

Reference: Ronjat, M., Feng, W., Dardevet, L., Dong, Y., Al Khoury, S., Chatelain, F. C., … & De Waard, M. (2016). In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide. Proceedings of the National Academy of Sciences, 113(17), E2460-E2468.