Product Name: Linaclotide
CAS No: 851199-59-2
Purity: 95%
Molar Mass: 1526.74
Chemical Formula: C59H79N15O21S6
Synonyms: Linzess, Constella
Storage: Store at -20℃
Sequence: CCEYCCNPACTGCY
Target: guanylate cyclase C
Application: Linaclotide (CAS: 851199-59-2) is a synthetic peptide agonist of guanylate cyclase-C (GC-C) receptors, primarily found in the intestinal epithelium. It functions by binding to GC-C receptors, leading to an increase in intracellular cyclic guanosine monophosphate (cGMP) levels. This cascade ultimately activates the cystic fibrosis transmembrane conductance regulator (CFTR) channels, promoting chloride and bicarbonate secretion into the intestinal lumen and enhancing intestinal fluid secretion. Linaclotide is used in the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) to alleviate constipation symptoms and improve bowel habits. In pharmaceutical chemistry, linaclotide’s targeted activation of GC-C receptors represents a novel approach to managing constipation, offering an effective and well-tolerated treatment option for patients with CIC and IBS-C. Its application underscores its importance in gastrointestinal therapeutics and improving quality of life for individuals with chronic constipation. Additionally, ongoing research explores linaclotide’s potential in other gastrointestinal disorders characterized by dysregulated intestinal motility and fluid balance, highlighting its versatility in gastroenterology.
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