Dirucotide

CAS No: 152074-97-0

Purity: 95%

Molar Mass: 2013.25

Chemical Formula: C92H141N25O26

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Product Name: Dirucotide

CAS No: 152074-97-0

Purity: 95%

Molar Mass: 2013.25

Chemical Formula: C92H141N25O26

Synonyms: MBP8298

Storage: Store at -20℃

Sequence: DENPVVHFFKNIVTPRT

Application: Dirucotide (CAS: 152074-97-0), also known as MBP8298, is a synthetic peptide under investigation for its potential therapeutic applications in multiple sclerosis (MS). It is derived from a portion of myelin basic protein (MBP), a major component of the myelin sheath in the central nervous system. Dirucotide is believed to act as a synthetic antigen, modulating the immune response and promoting immune tolerance to myelin antigens in MS patients. By inducing immune tolerance, dirucotide aims to reduce the autoimmune attack on myelin and potentially slow the progression of MS. In pharmaceutical chemistry, dirucotide represents a novel approach to treating MS, offering the potential to modify the disease course and improve outcomes for patients with this chronic autoimmune disorder. Clinical trials are ongoing to evaluate its safety, efficacy, and long-term effects in MS patients, with the goal of providing new treatment options for individuals affected by this debilitating disease.

Reference:

Boudesocque, L., Forni, L., Martinez, A., Nuzillard, J. M., Giraud, M., & Renault, J. H. (2017). Purification of dirucotide, a synthetic 17-aminoacid peptide, by ion exchange centrifugal partition chromatography. Journal of Chromatography A, 1513, 78-83.

Markowitz, C. (2008). Dirucotide (MBP8298) for the treatment of multiple sclerosis. Clinical Practice, 5(5), 605.