Difopein

Product Name: Difopein

CAS No: 396834-58-5

Purity: 95%

Molar Mass: 6387.2

Chemical Formula: C273H424N76O89S6

Storage: Store at -20℃

Sequence: SADGAPHCVPRDLSWLDLEANMCLPGAAGLDSADGAPHCVPRDLSWLDLEANMCLPGAAGLE

Target: 14.3.3 proteins

Application: Difopein is a synthetic peptide inhibitor that targets dimerization of the 14-3-3 protein, a key regulator of many cellular processes, including signal transduction, apoptosis, and cell cycle control. By preventing 14-3-3 dimers from interacting with their binding partners, Difopein disrupts 14-3-3-mediated signaling pathways. This peptide is extensively used in pharmaceutical and biochemical research to investigate the role of 14-3-3 in various diseases, such as cancer, neurodegenerative disorders, and metabolic diseases. Difopein’s ability to modulate 14-3-3 functions makes it a crucial tool for studying cellular regulatory mechanisms and developing therapeutic strategies.

Reference: Cao, W., Yang, X., Zhou, J., Teng, Z., Cao, L., Zhang, X., & Fei, Z. (2010). Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice. Apoptosis, 15, 230-241.