DiaPep277

Product Name: DiaPep277

CAS No: 179822-83-4

Purity: 95%

Molar Mass: 2390.73

Chemical Formula: C106H180N28O34

Synonyms: F8778UWB0A

Storage: Store at -20℃

Sequence: VLGGGVALLRVIPALDSLTPANED

Application: DiaPep277 (CAS: 179822-83-4) is a synthetic peptide-based immunomodulator used in the treatment of type 1 diabetes mellitus. It functions by modulating the immune response, specifically targeting T cells involved in the destruction of insulin-producing beta cells in the pancreas. DiaPep277 is derived from the sequence of heat shock protein 60 (HSP60), a protein involved in cellular stress response. It is believed to induce immune tolerance by stimulating regulatory T cells and shifting the immune response from a destructive to a regulatory phenotype. In pharmaceutical chemistry, DiaPep277 represents a novel approach to treating type 1 diabetes, offering the potential to preserve beta cell function and slow disease progression. Clinical trials have demonstrated promising results in terms of improving beta cell function, reducing insulin requirements, and achieving better glycemic control in patients with type 1 diabetes. Ongoing research continues to explore DiaPep277’s mechanisms of action, optimal dosing regimens, and long-term efficacy, with the goal of providing a safe and effective treatment option for individuals with type 1 diabetes.

Reference:

Raz, I., Ziegler, A. G., Linn, T., Schernthaner, G., Bonnici, F., Distiller, L. A., … & DIA-AID 1 writing group. (2014). Treatment of recent-onset type 1 diabetic patients with DiaPep277: results of a double-blind, placebo-controlled, randomized phase 3 trial. Diabetes Care, 37(5), 1392-1400.

Elias, D., Avron, A., Tamir, M., & Raz, I. (2006). DiaPep277 Preserves Endogenous Insulin Production by Immunomodulation in Type 1 Diabetes. Annals of the New York Academy of Sciences, 1079(1), 340-344.