CALP2

Product Name: CALP2

CAS No: 261969-04-4

Purity: 95%

Molar Mass: 1357.7

Chemical Formula: C68H104N14O13S

Storage: Store at -20℃

Sequence: VKFGVGFKVMVF

Target: calmodulin

Application: CALP2 is a synthetic peptide derived from the calpain family of calcium-dependent proteases. It functions as an activator of calpain enzymes, promoting the cleavage of specific substrate proteins involved in cellular processes such as cytoskeletal remodeling, signal transduction, and apoptosis. CALP2’s ability to enhance calpain activity makes it a useful tool in research focused on understanding the roles of calpain in neurodegeneration, muscle function, and cardiovascular diseases. Additionally, its potential therapeutic applications include the treatment of conditions associated with calpain dysregulation, such as Alzheimer’s disease, muscular dystrophy, and ischemic injury.

Reference: Chen, S. X., Wang, S. K., Yao, P. W., Liao, G. J., Na, X. D., Li, Y. Y., … & Zang, Y. (2018). Early CALP 2 expression and microglial activation are potential inducers of spinal IL‐6 up‐regulation and bilateral pain following motor nerve injury. Journal of neurochemistry, 145(2), 154-169.