Apraglutide

CAS No: 1295353-98-8

Purity: 95%

Molar Mass: 3765.25

Chemical Formula: C172H263N43O52

 

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Product Name: Apraglutide

CAS No: 1295353-98-8

Purity: 95%

Molar Mass: 3765.25

Chemical Formula: C172H263N43O52

Synonyms: FE 203799

Storage: Store at -20℃

Sequence: HGDGSFSDE-{Nle}-{d-Phe}-TILDLLAARDFINWLIQTKITD-NH2

Application: Apraglutide (CAS: 1295353-98-8) is a synthetic peptide analog of glucagon-like peptide-2 (GLP-2), a hormone involved in the regulation of gastrointestinal function and nutrient absorption. Apraglutide acts as a GLP-2 receptor agonist, stimulating intestinal growth and improving nutrient absorption in the small intestine. It has shown potential therapeutic applications in the treatment of gastrointestinal disorders characterized by intestinal failure, such as short bowel syndrome (SBS). By promoting intestinal growth and function, apraglutide may help reduce dependence on parenteral nutrition and improve overall nutritional status in patients with SBS. Clinical trials have demonstrated the efficacy and safety of apraglutide in increasing intestinal absorption, reducing diarrhea, and improving quality of life in patients with SBS. However, further research is needed to optimize dosing regimens, evaluate long-term safety, and explore additional therapeutic indications for apraglutide.

Reference: Eliasson, J., Hvistendahl, M. K., Freund, N., Bolognani, F., Meyer, C., & Jeppesen, P. B. (2022). Apraglutide, a novel glucagon‐like peptide‐2 analog, improves fluid absorption in patients with short bowel syndrome intestinal failure: findings from a placebo‐controlled, randomized phase 2 trial. Journal of Parenteral and Enteral Nutrition, 46(4), 896-904.