Product Name: Angiotensin II
CAS No: 4474-91-3
Purity: 95%
Molar Mass: 1046.18
Chemical Formula: C50H71N13O12
Storage: Store at -20℃
Sequence: DRVYIHPF
Target: AT1 Receptor
Application: Angiotensin II (CAS: 4474-91-3) is a potent vasoconstrictor peptide hormone that plays a central role in regulating blood pressure and fluid balance. It is formed through the enzymatic cleavage of angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II acts on angiotensin receptors, particularly the type 1 receptor (AT1 receptor), located in vascular smooth muscle cells, adrenal glands, and the brain. Upon binding to AT1 receptors, angiotensin II induces vasoconstriction, aldosterone release, sodium retention, and sympathetic nervous system activation, leading to increased blood pressure and fluid volume. In pharmaceutical chemistry, angiotensin II and its receptor antagonists represent important targets for the management of hypertension, heart failure, and kidney disease. Angiotensin II receptor blockers (ARBs) and ACE inhibitors are commonly prescribed medications that modulate the renin-angiotensin-aldosterone system to lower blood pressure and reduce cardiovascular risk. Understanding the biochemistry and pharmacology of angiotensin II has paved the way for the development of effective antihypertensive therapies, improving outcomes for patients with cardiovascular diseases. Additionally, ongoing research continues to elucidate the role of angiotensin II in various physiological processes and explore novel therapeutic strategies targeting this pathway.
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