740 Y-P

Product Name: 740 Y-P

CAS No: 1236188-16-1

Purity: 95%

Molar Mass: 3270.7

Chemical Formula: C141H222N43O39PS3

Synonyms: 740 Y-P, 1236188-16-1, PDGFR 740Y-P

Storage: Store at -20℃

Sequence: RQIKIWFQNRRMKWKKSDGGXMDMS

Application: 740 Y-P is a synthetic phosphopeptide that mimics a specific phosphorylated tyrosine residue found in signaling proteins. This peptide interacts with SH2 domains, which are key components in various intracellular signaling pathways, including the PI3K/Akt pathway. By binding to these domains, 740 Y-P activates PI3K, promoting cell growth, survival, and metabolism. In pharmaceutical and biochemical research, 740 Y-P is utilized to study signal transduction mechanisms, investigate cellular responses to growth factors, and screen potential inhibitors of PI3K signaling, which are relevant in cancer and other proliferative diseases.

Reference: Lin, F., Yang, Y., Wei, S., Huang, X., Peng, Z., Ke, X., … & Song, Y. (2020). Hydrogen sulfide protects against high glucose-induced human umbilical vein endothelial cell injury through activating PI3K/Akt/eNOS pathway. Drug design, development and therapy, 621-633.