H3K4(Me2) (1-20)

Purity: 95%

Molar Mass: 2211.6

Chemical Formula: C93H171N35O27

 

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Product Name: H3K4(Me2) (1-20)

Purity: 95%

Molar Mass: 2211.6

Chemical Formula: C93H171N35O27

Storage: Store at -20℃

Sequence: ARTKQTARKSTGGKAPRKQL

Application: H3K4(Me2) (1-20) is a synthetic peptide corresponding to the first 20 amino acids of histone H3, dimethylated at the lysine 4 (K4) residue. This specific post-translational modification is associated with actively transcribed genes and plays a pivotal role in the regulation of gene expression. Dimethylation of H3K4 marks both promoter regions and enhancers, facilitating the recruitment of transcriptional machinery. The H3K4(Me2) (1-20) peptide is a valuable tool in epigenetic research, enabling the study of chromatin dynamics, gene activation, and the molecular mechanisms involved in development, differentiation, and disease progression, particularly in the context of transcriptional regulation.

Reference: Ginsburg, D. S., Anlembom, T. E., Wang, J., Patel, S. R., Li, B., & Hinnebusch, A. G. (2014). NuA4 links methylation of histone H3 lysines 4 and 36 to acetylation of histones H4 and H3. Journal of Biological Chemistry, 289(47), 32656-32670.