H3K4(Me) (1-20)

Product Name: H3K4(Me) (1-20)

Purity: 95%

Molar Mass: 2197.6

Chemical Formula: C92H169N35O27

Storage: Store at -20℃

Sequence: ARTKQTARKSTGGKAPRKQL

Application: H3K4(Me) (1-20) is a synthetic peptide corresponding to the first 20 amino acids of histone H3, monomethylated at the lysine 4 (K4) residue. This specific post-translational modification is associated with gene activation and is often found at the promoters of actively transcribed genes. Monomethylation of H3K4 plays a critical role in the regulation of chromatin structure and gene expression, serving as a marker for enhancer elements. The H3K4(Me) (1-20) peptide is an essential tool in epigenetic research, aiding in the study of gene regulation, chromatin remodeling, and the mechanisms underlying development and disease, particularly in the context of transcriptional activation and cell differentiation.

Reference: Liu, Y., Qin, S., Chen, T. Y., Lei, M., Dhar, S. S., Ho, J. C., … & Min, J. (2019). Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4. Nature communications, 10(1), 36.