Gap19

Product Name: Gap19

CAS No: 1507930-57-5

Purity: 95%

Molar Mass: 1161.4

Chemical Formula: C55H96N14O13

Storage: Store at -20℃

Sequence: KQIEIKKFK

Target: Cx43 Hemichannel

Application: Gap19 is a therapeutic peptide that targets connexin 43 (Cx43) hemichannels, inhibiting their activity without affecting gap junctions. By selectively blocking these hemichannels, Gap19 prevents the uncontrolled release of ATP and other signaling molecules, reducing inflammation and cellular damage. This peptide shows promise in treating conditions such as cardiac ischemia, neuroinflammation, and stroke by protecting tissues from injury and enhancing recovery. Its targeted mechanism of action makes it a valuable tool in cardiovascular and neurological research, offering potential therapeutic benefits while minimizing side effects associated with broader connexin inhibition.

Reference: Chen, B., Yang, L., Chen, J., Chen, Y., Zhang, L., Wang, L., … & Yu, H. (2019). Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice. Brain research bulletin, 146, 124-135.