Product Name: Voclosporin
CAS No: 515814-01-4
Purity: 95%
Molar Mass: 1214.62
Chemical Formula: C63H111N11O12
Synonyms: ISAtx-247
Storage: Store at -20℃
Target: calcineurin (PP2B)
Application: Voclosporin (CAS: 515814-01-4) is a synthetic calcineurin inhibitor derived from cyclosporine A, used in the treatment of various autoimmune diseases, particularly lupus nephritis and other forms of nephrotic syndrome. It functions by selectively binding to cyclophilin within T-lymphocytes, thereby inhibiting calcineurin activity and preventing the dephosphorylation of nuclear factor of activated T-cells (NFAT). This cascade ultimately leads to the suppression of T-cell activation and the production of pro-inflammatory cytokines. In pharmaceutical chemistry, voclosporin’s targeted inhibition of calcineurin represents a significant advancement in the management of autoimmune kidney diseases, offering a more specific and potentially safer alternative to traditional immunosuppressive therapies like cyclosporine A. Its application underscores its importance in improving outcomes and quality of life for patients with lupus nephritis and other autoimmune kidney disorders. Additionally, ongoing research explores voclosporin’s potential in other autoimmune and inflammatory conditions, highlighting its versatility in immunomodulatory therapeutics.
Reference:
Heo, Y. A. (2021). Voclosporin: first approval. Drugs, 81, 605-610.
