Product Name: Etelcalcetide
CAS No: 1262780-97-1
Purity: 95%
Molar Mass: 1048.25
Chemical Formula: C38H73N21O10S2
Synonyms: AMG 416, KAI 4169
Storage: Store at -20℃
Sequence: CARRRAR
Target: CaSR
Application: Etelcalcetide (CAS: 1262780-97-1) is a synthetic peptide-based calcimimetic drug used in the treatment of secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD) on dialysis. It functions by mimicking the action of calcium at the calcium-sensing receptors (CaSR) on the parathyroid gland, thereby reducing the secretion of parathyroid hormone (PTH). By lowering PTH levels, etelcalcetide helps to control hypercalcemia, hyperphosphatemia, and bone disorders associated with SHPT. In pharmaceutical chemistry, etelcalcetide’s targeted modulation of CaSR represents a significant advancement in the management of CKD-MBD (chronic kidney disease-mineral and bone disorder), addressing a critical aspect of renal disease management and improving patient outcomes. Its application underscores its importance in optimizing mineral metabolism and reducing the risk of complications in CKD patients undergoing dialysis. Additionally, ongoing research explores etelcalcetide’s potential in other disorders characterized by dysregulated mineral metabolism, highlighting its versatility in endocrine and metabolic therapeutics.
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