Product Name: Nesiritide
CAS No: 124584-08-3
Purity: 95%
Molar Mass: 3464.04
Chemical Formula: C143H244N50O42S4
Synonyms: BNP 32, Human brain natriuretic factor-32, Natriuretic peptide type-B
Storage: Store at -20℃
Sequence: SPKMVQGSGC FGRKMDRISS SSGLGCKVLR RH
Target: NPRs
Application: Nesiritide (CAS: 124584-08-3) is a recombinant form of human B-type natriuretic peptide (BNP), a hormone produced by the heart ventricles in response to increased cardiac wall stress. It functions as a vasodilator and diuretic, primarily targeting natriuretic peptide receptors, particularly the type A receptor (NPR-A), located in vascular smooth muscle cells and the kidneys. Nesiritide promotes vasodilation, natriuresis, and diuresis, thereby reducing cardiac preload and afterload, as well as relieving fluid overload in conditions such as acute decompensated heart failure (ADHF). In pharmaceutical chemistry, nesiritide’s structure and mechanism of action make it a valuable therapeutic option for managing acute heart failure, providing rapid symptom relief and improving hemodynamic parameters. Its application underscores its significance in addressing the complex pathophysiology of heart failure and improving patient outcomes. Additionally, ongoing research explores nesiritide’s potential in other cardiovascular conditions and its role in combination therapies, highlighting its versatility in cardiovascular medicine.
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