Afamelanotide

Product Name: Afamelanotide

CAS No: 75921-69-6

Purity: 95%

Molar Mass: 1646.85

Chemical Formula: C78H111N21O19

Synonyms: CUV 1647, MBJ 05, Melanotan I

Storage: Store at -20℃

Sequence: SYSXEHFRWG KPV

Target: MC1R

Application: Afamelanotide (CAS: 75921-69-6) is a pharmaceutical compound notable for its applications in photoprotection and the management of certain skin conditions. As a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH), afamelanotide primarily acts by stimulating melanocytes, the pigment-producing cells in the skin. By promoting melanin production, afamelanotide enhances the skin’s natural defense against ultraviolet (UV) radiation. This targeted action makes it a valuable intervention in conditions such as erythropoietic protoporphyria (EPP), where individuals experience photosensitivity. Afamelanotide’s mechanism positions it as an innovative tool in the pharmaceutical armamentarium, offering a specific approach to mitigating the impact of sunlight exposure and improving the quality of life for individuals with certain photodermatoses.

Reference:

Wu, J., & Cotliar, R. (2021). Afamelanotide: An Orphan Drug with Potential for Broad Dermatologic Applications. Journal of Drugs in Dermatology: JDD, 20(3), 290-294.

Minder, A. E., Schneider-Yin, X., Zulewski, H., Minder, C. E., & Minder, E. I. (2023). Afamelanotide Is Associated with Dose-Dependent Protective Effect from Liver Damage Related to Erythropoietic Protoporphyria. Life, 13(4), 1066.